Overview

Effect of 2-h Infusion of ON 01910.Na in Ovarian Cancer Patients

Status:
Completed
Trial end date:
2011-07-01
Target enrollment:
0
Participant gender:
Female
Summary
ON 01910.Na has undergone preclinical and clinical phase I studies showing activity in patients with progressing ovarian cancer resistant to platinum-based chemotherapies. This study will look at a larger population of patients to determine whether treatment with ON 01910.Na has an effect on progression free survival rates in patients with platinum-resistant ovarian cancer. ON 01910.Na will be given as an intravenous infusion over 2 hours on days 1, 4, 8, 11, 15, and 18 of a 28-day cycle. Patients will be treated for 6 or more cycles.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Onconova Therapeutics, Inc.
Treatments:
ON 01910
Criteria
Inclusion Criteria:

- Women with ovarian cancer at least 18 years old with measurable disease who have shown
recurrent disease within 6 months of the last dose of cisplatin- or carboplatin-based
chemotherapy. Measurable disease will be defined as lesions that can be accurately
measured in at least one dimension with longest diameter ≥ 20 mm using conventional
techniques or ≥ 10 mm with spiral CT scan.

- Eastern Cooperative Oncology Group (ECOG) Performance Status 0, 1 or 2.

- No more than 3 prior chemotherapy regimens.

- Disease-free period of more than 5 years from prior malignancies other than ovarian
(except curatively treated basal cell carcinoma, squamous cell carcinoma of the
skin,or carcinoma in situ of the cervix).

- All female patients of childbearing potential must use at least one form of
contraception as approved by the Investigator prior to study entry and for up to 30
days beyond the last administration of study drug.

- Women of childbearing potential must have a negative serum βHCG pregnancy test at
screening.

- Willing to adhere to the prohibitions and restrictions specified in this protocol.

- Patient (or her legally authorized representative) must have signed an informed
consent document.

Exclusion Criteria:

- Evidence of complete or partial bowel obstruction.

- Need for IV hydration or Total Parenteral Nutrition.

- Inability to comply with study and/or follow-up procedures.

- Life expectancy of less than 12 weeks.

- Prior radiotherapy to greater than one third of hematopoietic sites.

- Uncontrolled intercurrent illness including, but not limited to symptomatic congestive
heart failure, unstable angina pectoris or cardiac arrhythmia.

- Active infection not adequately responding to appropriate therapy.

- Hyponatremia (defined as serum sodium value of <134 mEq/L).

- Total bilirubin ≥ 1.5 mg/dL not related to hemolysis or Gilbert's disease, AST/ALT or
alkaline phosphatase ≥ 2 X ULN.

- Serum creatinine ≥ 2.0 mg/dL.

- ANC < 1500/mm3, platelets < 100,000/mm3; hemoglobin less than 9 g/dL.

- Ascites requiring active medical management including paracentesis for more than twice
a month.

- Women patients who are pregnant or lactating or have a positive serum βHCG pregnancy
test at screening.

- Major surgery without full recovery or major surgery within 3 weeks of ON 01910.Na
treatment start.

- Uncontrolled hypertension (defined as a systolic pressure ≥ 160 and/or a diastolic
pressure ≥ 110).

- New onset seizures (within 3 months prior to the first dose of ON 01910.Na) or poorly
controlled seizures.

- Brain metastases including any of the following:

1. Evidence of cerebral edema by CT scan or MRI.

2. Evidence of disease progression on prior imaging studies.

3. Requirement for steroids.

4. Clinical symptoms of brain metastases.

- Any concurrent and/or within 4 weeks of the first dose of study drug investigational
agent or chemotherapy, radiotherapy or immunotherapy.

- Psychiatric illness/social situations that would limit the patient's ability to
tolerate and/or comply with study requirements.