Effect Sildenafil and Estradiiol Valerate on Endometrial Thickness in Infertile Women
Status:
Completed
Trial end date:
2018-07-30
Target enrollment:
Participant gender:
Summary
The endometrium is a dynamic tissue that responds to changing hormonal signals throughout the
cycle. The changes in the endometrial composition are expressed in alteration in gene
expression, micro architectural morphological changes as well as in protein and hormone
secretion. These factors combine together to construct the "window of implantation" a short
period of time during the luteal phase in which the endometrium is receptive.
Thin endometrium is associated with a low pregnancy rate. Endometrial thickness 7 mm in the
pre-ovulatory phase is widely accepted to be cut-off of thin endometrium.
for that the aim of this study is to compare the effect of sildenafil-estrogen combination to
estrogen alone on endometrium thickness in infertile women. Half of the patients will receive
estrogen ( estradiol valerate ) and the other half will receive combination of
sildenafil-estrogen .