Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation
Status:
Completed
Trial end date:
2018-03-01
Target enrollment:
Participant gender:
Summary
Chronic obstructive pulmonary disease (COPD) patients often undergo thoracic surgery due to
lung cancer and emphysematous changes. One lung ventilation (OLV) used in thoracic surgery
aggravates hypoxia and hypercapnia increasing intrapulmonary shunt and dead space.Ketamine
provide bronchodilation by inhibiting the reuptake of catecholamines in the circulation. It
also serves relaxation of bronchial smooth muscle. Our aim in this study, effects of ketamine
on arterial oxygenation, the shunt fraction and the lung mechanics in patients with COPD who
administered OLV because of thoracic surgery. Thirty patients with COPD who undergo
thoracotomy for lung lobectomy will be included in this study. Patients will be randomly
divided to a control group (%0,9 saline- CG) or a keta (ketamine- KG) group. KG will be
administered 1 mg/kg ketamine bolus, then 0,5 mg/kg/hour ketamine infusion after the
induction, CG will be administered sline bolus, then saline infusion. Peak airway pressure
(Ppeak), plato airway pressure (Pplato), static compliance, shunt fraction, PaO2/FiO2 and
arteriel blood gas values (Pa02, PaC02) will be recorded before initiation of OLV and 30
minutes intervals after initiation of OLV.To evaluate the postoperative pulmonary
complications, Pa02, PaC02 in blood gas and Pa02/Fi02 values will be recorded 20 minute after
arrival at postoperative care unit. Patients will be evaluated for pneumonia, atelectasis and
acute lung injury at postoperative 72 h and findings will be recorded. 30 day mortality will
be recorded.