Effect Of Anti TNF Alpha Therapy And Their Adverse Effects In Ankylosing Spondylitis In A North Indian Population
Status:
Completed
Trial end date:
2012-01-01
Target enrollment:
Participant gender:
Summary
Ankylosing Spondylitis (AS) is a chronic painful progressive inflammatory arthritis of
unknown etiology primarily affecting the spine and sacroiliac joints. In addition to
formation of new bone leading to syndesmophytes and ankylosis; osteoporosis is also a
prominent feature in AS-thus showing the paradox of new bone formation at abnormal sites
coexisting with reduced bone mass & increased fracture risk. Osteoporosis is a common
complication of AS, with an incidence between 18.7% and 62%. TNF alpha has a central role in
disturbing this balance in bone metabolism--resulting in accelerated alveolar bone loss and
decreased strength- i.e. osteoporosis. The investigators hypothesis that anti TNF therapy is
effective in active AS resistant to conventional therapy and helps in improving the bone
density and over all bone health.
Phase:
N/A
Details
Lead Sponsor:
All India Institute of Medical Sciences, New Delhi