Overview

Echocardiographic Study of a Single Dose Bisoprolol Versus Nebivolol in Healthy Subjects

Status:
Not yet recruiting
Trial end date:
2022-12-01
Target enrollment:
0
Participant gender:
All
Summary
This is a randomized, double-blind, crossover study in healthy adult subjects. Each subject will receive a single dose of bisoprolol 5 mg p.o. and nebivolol 5 mg p.o. with 1 week washout period. All subjects will undergo a physical examination, 12-lead electrocardiography and a comprehensive echocardiographic study before the administration of the study drug and 5 hours thereafter.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Clinical Hospital Center Zemun
Treatments:
Bisoprolol
Nebivolol
Criteria
Inclusion Criteria:

1. Healthy subjects (male and female)

2. Age interval: 20-60 years old (inclusive)

Exclusion Criteria:

1. Any known absolute or relative contraindication to beta-blocker therapy

2. Poor echogenicity

3. A resting heart rate <60 bpm

4. A resting blood pressure < 110/70 mmHg