Echocardiographic Evaluation of the Effects of Dexmedetomidine in Diastolic Dysfunction
Status:
Completed
Trial end date:
2015-08-01
Target enrollment:
Participant gender:
Summary
Dexmedetomidine is a selective α2 adrenergic agonist that can be considered a primary
anesthetic, an adjuvant to propofol or inhalational anesthetics. Dexmedetomidine mediate its
cardiovascular effect through activation of receptors in central and peripheral nervous
system. The classic cardiovascular response of dexmedetomidine is the biphasic with initial
shorten-increase in blood pressure followed by long-lasting decrease in BP and HR. There were
several reports about these hemodynamic changs of dexmedetomidine, but not the evaluation of
direct cardiac function of patients who was preexisted diastolic dysfunction. The purpose of
this study is to evaluate the effects of dexmedetomidine as an anesthetic adjuvant in
diastolic dysfunction by using the echocardiography.