Overview

Early rhBNP on Myocardial Remodeling and Reperfusion in Patients With STEMI

Status:
Unknown status
Trial end date:
2021-08-01
Target enrollment:
0
Participant gender:
All
Summary
The study intends to evaluate the efficacy of early rhBNP on myocardial remodeling and reperfusion in patients with ST-segment elevation myocardial infarction after percutaneous coronary intervention
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
RenJi Hospital
Criteria
Patients are eligible for enrollment if they are suspected as anterior myocardial infarct
(anterior myocardial infarct is defined as persistent chest pain for 30 mins at least, with
ST-segment elevation of at least 0.2 mV in two or more contiguous precordial leads) within
12 hours after onsets of symptom, and no contraindication for rhBNP. The coronary
angiography (CAG) proves left anterior descending (LAD) as culprit vessel, which was
totally or nearly occlusion with TIMI 0-1 grade and resulted in TIMI 3 grade after PCI.

Exclusive criteria:

1. Killips grade III-IV.

2. unstable hemodynamic; with A-V block or atrial fibrillation;

3. Contraindication of magnetic resonance, such as history of metal, ICD or paceman
implant;

4. history of myocardial infarct;

5. pregnancy or breeding;

6. combined with other serious diseases: severe renal dysfunction (creatinine
clearance<30ml/min;), liver failure, neutropenia, thrombocytopenia, acute
pancreatitisï¼›

7. life expectancy≤12 months