Early-onset Ventilator-associated Pneumonia in Adults: Comparison of 8 Versus 15 Days of Antibiotic Treatment
Status:
Completed
Trial end date:
2002-11-01
Target enrollment:
Participant gender:
Summary
The duration of treatment of community acquired pulmonary infection varies between 5 and 14
days according to the authors (22), or even 3 days with new drugs having long half-life (2).
For nosocomial pulmonary infection, treatment durations are not standardized (5). It is
simply mentioned the concept of "usual" treatment of at least 15 days. However, recent
studies used 10 days of treatment without significant decrease in the rate of healing
compared to usual treatment. It is essential to clarify the optimal duration of antibiotic
treatment. Indeed, any excessive extension of treatment may increase the occurrence of
adverse effects (renal toxicities, hepatic...), and induce resistance of bacteria to
antibiotics (selection pressure), colonization of the patient by Multiresistant bacteria and
an increase in the cost of treatment
Phase:
Phase 4
Details
Lead Sponsor:
Centre Hospitalier Universitaire de Besancon
Collaborators:
French Society for Intensive Care GlaxoSmithKline SmithKline Beecham