While it is known that Dupilumab has profound effects in patients with CRSwNP, these are
often seen months later after treatment initiation; however, in practice, patients often
endorse feeling significantly better within days of their first injection. No studies have
investigated the molecular basis for such an acute change. This study proposes that specific
cytokine changes in phenotype in addition to microbiome and oscillometry effects play a
synergistic role in producing this effect.