Early and Adequate Protein Feeding Post-Traumatic Injury
Status:
Completed
Trial end date:
2019-10-18
Target enrollment:
Participant gender:
Summary
A randomized, parallel-group, pilot study comparing the effect of the early addition of
intravenous protein to enteral feeding as tolerated versus enteral feedings as tolerated
alone immediately post traumatic injury.
Primary: To determine that early and adequate nutritional support will improve protein
economy in the first week post -injury as measured by nitrogen balance. We hypothesize that
an improvement in nitrogen balance with early maximized protein intake will support the
production of acute phase proteins, major antioxidants and the inflammatory response.
Secondary: Through the use of mass spectrometry (MS) and nuclear magnetic resonance (NMR)
technologies we will determine that our plan for early and adequate nutritional support with
adequate protein from day one post injury will alter the metabolomics profile when compared
to routine nutritional support.
Tertiary: For Specific Aim 3 we will measure several pro- and anti-inflammatory cytokines and
soluble proteins.
Phase:
Early Phase 1
Details
Lead Sponsor:
Boston Medical Center
Collaborators:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) National Institutes of Health (NIH)