Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants
Status:
Completed
Trial end date:
2010-05-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate the early use of hydrocortisone in hypotensive
very low birth weight infants.
Based on the observations that:
- hypotension is a common problem in very low birthweight infants and is associated with
brain injury and poor neurological outcomes;
- some infants are refractory to standard treatment (volume expansion and vasopressors),
which is not exempt of adverse effects;
- relative adrenal insufficiency has been described in this population; we hypothesize
that hydrocortisone is effective in the treatment of hypotension in this population and
reduce the need for vasopressors.