Early TIPS With Polytetrafluoroethylene (PTFE) Covered Stents for Acute Variceal Bleeding in Patients With Advanced Cirrhosis

• Status: Completed
• Trial end date: 2018-09-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether early use of transjugular intrahepatic portosystemic shunt (TIPS) with Polytetrafluoroethylene (PTFE) covered stents is able to prolong the survival in patients with advanced cirrhosis and acute variceal bleeding.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Air Force Military Medical University, China; Fourth Military Medical University
• Treatments: Adrenergic beta-Antagonists; Propranolol

Criteria

Inclusion Criteria:

• History of cirrhosis (clinical or by liver biopsy)

• Admission due to acute bleeding from oesophageal or gastric (GOV1 or GOV2) varices

• Child-Pugh Class C (Child-Pugh score less than or equal to 13) or Child-Pugh class B

• Signed written informed consent

Exclusion Criteria:

• Patients not fulfilling inclusion criteria

• Pregnancy or breast-feeding

• Confirmed hepatocellular carcinoma

• Creatinine greater than 3 mg/dl

• Terminal hepatic failure (Child-Pugh score greater than 13)

• Previous treatment with TIPS or combined pharmacological and endoscopic treatment to prevent rebleeding

• Fundal or ectopic gastric variceal bleeding (IGV1 or IGV2)

• Complete portal vein thrombosis or portal cavernoma

• Congestive heart failure New York Heart Association (NYHA) greater than III or medical history of pulmonary hypertension

• Spontaneous recurrent hepatic encephalopathy