Early Predictors of Poor Treatment Response in Patients With Schizophrenia Treated With Atypical Antipsychotics
Status:
Completed
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
Background: The aims of this study were to explore the relationship between early reduction
in psychotic symptoms and the ultimate response in patients with schizophrenia treated by
atypical antipsychotics, and to determine the best time to switch or maitain the regimen. PI
also explore the possible predictors for the clinical response.
Methods: One hundred eleven inpatients with acutely exacerbated schizophrenia were randomized
to give optimal therapy of olanzapine, risperidone, and paliperidone in one-week run-in
period and 12 weeks' intervention. All participants were assessed using Positive and Negative
Syndrome Scale (PANSS). Early Response, defined as reduction of 25% in PANSS score, was
examined at weeks 1, 2, 3, 4 and 8, and these ratings were used to predict ultimate response
(25% PANSS reduction) at week 12. PI hypothesized that early treatment response at Week 1 or
2 could predict Week 12's treatment outcome.