Early Precise Diagnosis and Intervention of CPT Based on a Noninvasive 3D-vHPS
Status:
Active, not recruiting
Trial end date:
2020-06-01
Target enrollment:
Participant gender:
Summary
The aim of this study is to investigate the possibilities of early and precise management to
decrease portal vein pressure in cirrhotic patients, guided by a non-invasive
3D-virtual-model of hepatic portal system (3D-vHPS). Healthy volunteers are enrolled to
determine the normal range of pressure density in different sites of HPS. Cirrhotic patients
without visible gastro-esophageal varies by endoscopy are randomly enrolled to virtual portal
vein pressure gradient (vPVPG) monitored or non-vPVPG monitored groups. Non-vPVPG groups are
followed-up and treated according to Baveno V consensus in portal hypertension. Patients in
vPVPG-monitored groups are followed-up by anatomic computed tomographic angiography (CTA) and
Doppler ultrasound every six months. Once vPVPG is above 12mm of mercury (Hg), participants
will receive carvedilol treatment. All cirrhotic patients are followed-up with the incidence
of portal hypertension-related complications, mortality rate and life quality assessment.
Phase:
Phase 4
Details
Lead Sponsor:
Changqing Yang
Collaborators:
Shanghai 10th People's Hospital Shanghai Changzheng Hospital Shanghai East Hospital,Tongji University School of Medicine Shanghai Tenth People's Hospital,Tongji University School of Medicine Xinhua Hospital, Shanghai Jiaotong University School of Medicine