Early Oral Step-down Antibiotic Therapy for Uncomplicated Gram-negative Bacteraemia
Status:
Not yet recruiting
Trial end date:
2025-03-01
Target enrollment:
Participant gender:
Summary
Current management of uncomplicated Gram-negative bacteraemia entails prolong intravenous
(IV) antibiotic therapy with limited evidence to guide oral conversion. This trial aim to
evaluate the clinical efficacy and economic impact of early step-down to oral antibiotics
(within 72 hours from index blood culture collection) versus continuing standard of care IV
therapy (for at least another 48 hours post-randomisation) for clinically stable /
non-critically ill inpatients with uncomplicated Gram-negative bacteraemia.
Phase:
Phase 3
Details
Lead Sponsor:
Tan Tock Seng Hospital
Collaborators:
Changi General Hospital Imperial College Healthcare NHS Trust John Hunter Hospital Melbourne Health National University Hospital, Singapore Ng Teng Fong General Hospital Royal Brisbane and Women's Hospital Samsung Medical Center Sengkang General Hospital Singapore Clinical Research Institute Singapore General Hospital University of Malaya