Early Goal Directed Sedation on Microcirculation in Septic Shock

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators will conduct a prospective, single-center, randomized, double-blinded, controlled study to investigate the effect of early goal directed sedation on microcirculation in early septic shock patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Southeast University, China
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• Septic shock patients despite early goal directed therapy

• Required sedation

Exclusion Criteria:

• Age< 18

• Pregnancy

• Bradycardia (HR<55bpm)

• Systolic blood pressure < 80 mmHg / mean arterial pressure < 50 mmHg on maximal support

• Death imminent

• Unlikely to survive 90 days

• Acute liver failure

• Dementia

• High-grade block in the absence of a functioning pacemaker.