Early Detection of Atherosclerosis: a Randomized Trial in the Primary Prevention of Cardiovascular Diseases.

• Status: Unknown status
• Trial end date: 2013-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The incidence of cardiovascular diseases is still high and further efforts should be done in primary prevention. The main objective is to quantify the burden of subclinical atherosclerosis using non-invasive techniques,and to study the impact of this assessment and consequent treatment in the progression of atherosclerosis and in the incidence of cardiovascular diseases.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hospital Arnau de Vilanova
• Collaborator: Pfizer
• Treatments: Angiotensin-Converting Enzyme Inhibitors; Aspirin; Atorvastatin; Atorvastatin Calcium; Clopidogrel; Diuretics; Enalapril; Enalaprilat; Rimonabant; Simvastatin

Criteria

Inclusion Criteria

One or more of the following:

• Familiar History of early-onset cardiovascular disease (male < 55 or female < 65).

• Type 2 Diabetes mellitus or type 1 with microalbuminuria.

• Essential High Blood Pressure.

• Chronic Kidney Disease.

• Primary hyperlipidemia.

The presence of two or more of the following:

• Current smoker.

• Physical inactivity.

• High blood pressure (recently diagnosed).

• Abdominal perimeter: > 102 cm. males; > 88 cm. females.

• Total cholesterol > 240 mg/dL.

• HDL cholesterol ≤ 40 mg/dL males, ≤ 50 mg/dL females.

Exclusion Criteria:

• Age < 40 or > 74 years old.

• Previous Cardiovascular Event.