Early Albumin Resuscitation During Septic Shock

• Status: Completed
• Trial end date: 2011-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Objective: To determine whether the early administration of albumin as an expander and antioxidant would improve survival on the 28th day for septic shock patients.

Design: Prospective, multicenter, randomized, controlled versus saline, stratified on nosocomial infection and center.

Setting: 27 Intensive Care Units (ICU) in France

Coordinator: Pr J.P. Mira and Dr J. Charpentier - Cochin Hospital- Paris

Patients: 800 patients could be included during the first 6 hours of their septic shock.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Laboratoire français de Fractionnement et de Biotechnologies

Criteria

Inclusion Criteria:

• Over 18 years old

• Septic shock < 6 hours

• Agreement of patients

Exclusion Criteria:

• Allergy to albumin

• Weight > 120 kg

• Non septic shock

• Burned

• Cirrhosis

• Albumin perfusion 48 hours before randomization

• Pregnant women

• Cardiac dysfunction New York Heart Association (NYHA) 3 or 4

• Patients with therapeutic limitation