Early Administration of Edoxaban After Acute Ischemic Stroke in Patients With Non-valvular Atrial Fibrillation
Status:
Completed
Trial end date:
2020-07-02
Target enrollment:
Participant gender:
Summary
The investigators hypothesize that earlier initiation of edoxaban in AF-related stroke
patients may significantly reduce the early recurrence of ischemic stroke, compared with
conventional strategy of anticoagulation following 1-3-6-12 rule. To expedite the
verification of the hypothesis, the investigators are planning to use diffusion weighted
imaging (DWI), which has been reported to be a surrogate to predict both short-term and
long-term prognosis after stroke, to detect the recurrent ischemic events. Because data on
the early anticoagulation in patients with AF-related stroke are limited, the investigators
decided to perform a pilot study before establishing an appropriate clinical trial protocol.
This study will help estimate the efficacy and safety of early administration of edoxaban,
and determine the sample size of a following clinical trial. To ensure the safety in this
pilot exploration, the investigators will not include patients with severe ischemic strokes,
who are often prone to experience hemorrhagic transformation in the acute post-stroke period.
Phase:
Phase 2
Details
Lead Sponsor:
Jong Sung Kim
Collaborators:
Dong-A University Hospital Kyung Hee University Hospital Soon Chun Hyang University