EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement

• Status: Recruiting
• Trial end date: 2023-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This phase II trial investigates the effect of EXPAREL compared to lidocane as a local anesthetic in patients who are undergoing pleuroscopy with pleural biopsy and indwelling pleural catheter placement. This trial aims to see whether EXPAREL or lidocane is able to make patients more comfortable.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: M.D. Anderson Cancer Center
• Treatments: Bupivacaine; Lidocaine

Criteria

Inclusion Criteria:

• Referral to pulmonary services for pleuroscopy with biopsies and indwelling pleural catheter (IPC) placement

• Age > 18

Exclusion Criteria:

• Inability to provide informed consent

• Study subject has any disease or condition that interferes with safe completion of the study including:

• Allergic reaction to EXPAREL

• Need for pleurodesis

• No placement if IPC

• Previous ipsilateral thoracic surgery

• Allergies to lidocaine or other local anesthetics, narcotics, non-steroidal anti-inflammatory drugs (NSAIDs) or acetaminophen

• Pregnancy

• Advanced liver disease where the clinician deems the procedure unsafe