ET 50 for Post Caesarean Section Spinal Hypotension
Status:
Completed
Trial end date:
2014-05-01
Target enrollment:
Participant gender:
Summary
Hypotension is extremely common after induction of spinal anesthesia for cesarean delivery.
Anesthetic blockade of the sympathetic outflow of the spinal cord causes vasodilation, and is
one cause of this hypotension. The higher the spread of the blockade will result in a higher
incidence of hypotension. Injected hyperbaric medication has about 15 minutes to spread
within the intrathecal space before it will be taken up by the nerve roots. The time that a
patient remains in one position after medication injection will affect the spread of the
resultant anesthetic block. A patient who is left sitting for a longer period of time after
injection of hyperbaric medication will have a lower level of block than someone who is
placed supine immediately. In this study, the investigators wish to use up down sequential
analysis to determine the time period a patient should remain seated after intrathecal
injection of hyperbaric bupivacaine that will result in a 50% rate of hypotension.
Phase:
Phase 2
Details
Lead Sponsor:
McGill University Health Center McGill University Health Centre/Research Institute of the McGill University Health Centre