The purpose of this pilot study is to assess the analgesic efficacy of Erector Spinae Plane
block (ESPB) with liposomal bupivacaine in women undergoing cesarean delivery and receiving a
postoperative multimodal analgesic regimen as assessed by the dose of rescue postoperative
opioids compared to a historical control group of women receiving the same multimodal regimen
but with no truncal blocks. This will be a case control study with a prospective and a
retrospective component. Women undergoing elective cesarean delivery under spinal or combined
spinal epidural anesthesia will be approached to participate in the prospective open label
component of the study. Cases will be matched in a 1:4 ratio by age, race, history of prior
cesarean delivery, and insurance status with historical controls who received the same
multimodal analgesic regimen but no truncal blocks. We plan to enroll 30 subjects for the
prospective arm of the study and 120 for the retrospective arm.