EP4-receptor Antagonism and Prostaglandin E2 (PGE2) in a Human Headache Model

• Status: Completed
• Trial end date: 2010-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether EP-4 receptor antagonist can prevent the headache expected during a Prostaglandin E2 infusion.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Danish Headache Center
• Treatments: Dinoprostone

Criteria

Inclusion Criteria:

• Healthy volunteers

Exclusion Criteria:

• Tension headache

• All other primary forms of headache

• Cardiovascular, Central Nervous system (CNS) and autoimmune diseases

• Gastrointestinal disease

• Previous or clinical signs of mental illness or substance abuse.

• Participation in a clinical study of a medicinal product without regulatory approval or marketing authorisation within 1 month prior to this trial

• Pregnancy/nursing

• Daily intake of medication (except oral contraceptives)