EFFECT OF ADDING DAPAGLIFLOZIN TO ALLOGRAFT DYSFUNCTION OF RENAL TRANSPLANTED PATIENTS.
Status:
Not yet recruiting
Trial end date:
2023-03-01
Target enrollment:
Participant gender:
Summary
Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce plasma glucose and haemoglobin
A1c(HbA1c) in patients with type 2 diabetes mellitus by increasing urinary glucose excretion
in a non-insulin-dependent fashion.
However, in some situations lead to a diminished number of functional glomeruli with a
consequent hyperfiltration in the remaining ones. This fact may be where the use of SGLT2
inhibitor could attenuate the renal damage.
The purpose of our study is to evaluate the impact of using dapagliflozin on the renal
functional deterioration of renal transplanted patients diabetics or not.
This is a prospective, randomized, single-blinded, double-center, controlled trial.
Patients will be randomized to add either Dapagliflozin 10 mg or Placebo to their treatment.
Study drug will be administered by once-daily orallly. The first dose MUST be started within
1 and 7 days after randomization. The subsequent doses will be administered 24 ± 4 hours
after the previous dose.