Overview

EEG Characteristics in ECT

Status:
Unknown status
Trial end date:
2020-10-01
Target enrollment:
0
Participant gender:
All
Summary
The investigators will be examining slow-wave characteristics in depressed patients receiving electroconvulsive therapy (ECT) using direct current electroencephalogram (dcEEG) by anesthesia induction agent.
Phase:
Early Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of New Mexico
Collaborator:
University of New Mexico Clinical & Translational Science Center
Treatments:
Ketamine
Methohexital
Criteria
Inclusion Criteria:

- Structured Clinical Interview for DSM-5 will confirm diagnosis of MDD or BPD-depressed
(with or without psychotic features

- The clinical indications for ECT including treatment resistance or a need for a rapid
and definitive response;

- Hamilton Depression Rating Scale 24-item (HDRS-24) > 21; and

- Age range between 18 and 65 years of age.

Exclusion Criteria:

- Defined neurological or neurodegenerative disorder (e.g., history of head injury with
loss of consciousness > 5 minutes, epilepsy, Alzheimer's disease);

- Other psychiatric conditions (e.g., schizophrenia, schizoaffective disorder, bipolar
disorder)

- Current drug or alcohol use disorder, except for nicotine and marijuana

- Adults unable to consent, pregnant women, prisoner

- Non-English speakers

- Patients that cannot tolerate Methohexital and Ketamine.