EEG Analysis During Light Propofol Sedation

• Status: Recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: Male

Summary

The hypothesis of this study is that propofol sedation does not affect the detectability of a movement intention in the EEG motor cortex signal. EEG signals will be recorded during the realization of intentional movements and movement intentions by the healthy volunteers, as well as during median nerve stimulation before and during propofol perfusion according to a target control infusion. (0 µg/mL; 0.5 µg/mL and 1 µg/mL).

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Central Hospital, Nancy, France
• Collaborators: CHRU de Nancy, Departement of anesthesiology & Intensive Care Medicine; Institut National de Recherche en Informatique et Automatisme (INRIA); Université de Lorraine (UL)
• Treatments: Propofol

Criteria

Inclusion Criteria:

• Healthy volunteers

• Male

• affiliated to French social security

• normal physical examination

• 22 < body mass index < 28

Exclusion Criteria:

• Female

• allergy to propofol or one of the emulsion compounds (soja, egg)

• any pathology which may influence EEG recording or nerve conduction, such as diabetes, neuropathy, epilepsy, depression, psychotropic drug usage, drug usage)

• any allergic reaction associated with anesthesia