ED90 of Bupivacaine After Lidocaine Test Dose With DPE and EPL
Status:
Not yet recruiting
Trial end date:
2025-12-31
Target enrollment:
Participant gender:
Summary
The primary objective of our study is to use a biased coin up-down allocation methodology to
estimate the dose of bupivacaine required after the lidocaine test dose to achieve initial
effective comfort in 90% of patients (post test-dose ED90) via the epidural (DPE or EPL)
technique in women undergoing labor induction or augmentation; we hypothesize that we will be
able to determine the post test-dose ED90 of bupivacaine for each technique with adequate
precision to inform the optimal doses to study in a subsequent randomized trial comparing the
analgesic effects of DPE vs. EPL. We also hypothesize that the post test-dose ED90 of
bupivacaine is lower with a DPE technique than with a conventional epidural technique.