ED90 of 3% Chloroprocaine for Cervical Cerclage

• Status: Completed
• Trial end date: 2020-10-23
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of this study is to identify the dose of intrathecal (IT) chloroprocaine that provides effective anesthesia in 90% of patients undergoing elective cerclage placement (intraoperative analgesic supplementation not required).

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Duke University
• Collaborator: University of Arkansas
• Treatments: Chloroprocaine; Fentanyl; Procaine

Criteria

Inclusion Criteria:

• ≥ 18 years of age

• Singleton pregnancy

• ASA class II or III

• Cervical cerclage 1st or 2nd trimester of pregnancy

• Simple prophylactic cervical cerclage

Exclusion Criteria:

• Patient refusal

• Abdominal and complex cervical cerclage (e.g. bulging bag)

• BMI ≥ 50 kg/m2

• ASA class IV or above

• Contraindication to neuraxial anesthesia

• Allergy to chloroprocaine