ED Influenza Therapeutic Pilot Study: Oseltamivir vs. Peramivir
Status:
Completed
Trial end date:
2018-05-31
Target enrollment:
Participant gender:
Summary
This pilot study is designed to demonstrate the feasibility of utilizing Emergency
Departments (EDs) as a primary site for subject enrollment in clinical trials evaluating
influenza therapeutics, and to provide pilot data for future clinical trial design and
planning.
Primary Objective: To prospectively enroll high-risk subjects with laboratory-confirmed
influenza into a randomized, open label study of oral versus IV influenza therapeutic to
include symptom evaluation and outcome assessments.
Secondary Objective 1: To identify influenza positive patients utilizing a previously
established triage-based assessment and rapid testing algorithm for suspected influenza
infection.
Secondary Objective 2: To retrospectively evaluate all potentially eligible patients for
potential enrollment biases.
Secondary Objective 3: To create a repository of residual nasopharyngeal samples collected
from ED patients with suspected influenza illness.