E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder
Status:
Not yet recruiting
Trial end date:
2026-03-01
Target enrollment:
Participant gender:
Summary
The purpose of this an open-label, randomized controlled trial study is to compare the
effectiveness of electronic cigarettes (e-cigarettes/e-cigs) with telehealth motivational
counseling with combination nicotine replacement therapy (NRT) + telehealth counseling on
combustible cigarettes smoking reduction among persons with opioid use disorder (OUD) in
methadone and buprenorphine treatment programs (opioid use disorder treatment programs
(OUDTP)). OUDTP patients are a population with exceptionally high combustible cigarettes
smoking burden and yet limited success in achieving meaningful clinical outcomes in tobacco
treatment. If effective, electronic cigarettes would provide an additional tool for tobacco
harm reduction among this difficult-to-treat vulnerable population.