Dynamics of Insulin Absorption in Subclinical Lipohypertrophy Using the Euglycemic Clamp Technique

• Status: Suspended
• Trial end date: 2023-04-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will use the euglycemic clamp technique to evaluate insulin absorption when insulin is administered subcutaneously in an area of subclinical lipohypertrophy vs an area of normal tissue.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Graydon Meneilly
• Treatments: Insulin; Insulin Lispro; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Participated in Glycemic Variability study

• Type 2 Diabetes for at least 2 years

• Currently using insulin to manage diabetes

• Have used insulin to manage diabetes for at least 2 years

• Age 19 or older

• BMI < 30 kg/m2

• Confirmed areas of subclinical lipohypertrophic adipose tissue lesions via ultrasound

Exclusion Criteria:

• Taking other injectable medications (eg liraglutide/Victoza

• Taking systemic steroids (ie prednisone)

• Severe renal insufficiency (eGFR < 30 ml/min/1.73 m2

• Hypoglycemic unawareness

• Current pregnancy

• Not fluent in speaking and writing English (unless accompanied by a translator)