Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis

• Status: Completed
• Trial end date: 2014-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the best duration(3 versus 6 weeks) of antibiotics as part of maximal medical therapy for treating chronic sinusitis and thus preventing patients from having to have sinus surgery. The hypothesis is that in the context of maximal medical therapy 3 weeks of antibiotics is not worse than 6 weeks of antibiotics at successfully treating chronic sinusitis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of North Carolina, Chapel Hill
• Treatments: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Azithromycin; Doxycycline

Criteria

Inclusion Criteria:

• Diagnosis of chronic rhinosinusitis

• 18 years of age or older

• English speaking

Exclusion Criteria:

• Pregnant or breastfeeding women

• vasculitis

• cystic fibrosis

• primary ciliary dyskinesia

• allergic fungal sinusitis

• gross immunodeficiency

• current use of chemotherapy

• insulin-dependent diabetes mellitus

• recent trial of maximal medical therapy