Durability of Hypertonic Saline for Enhancing Mucociliary Clearance in Cystic Fibrosis
Status:
Completed
Trial end date:
2010-05-01
Target enrollment:
Participant gender:
Summary
Direct measurement of mucociliary and cough clearance (MCC/CC) has been used as a biomarker
in cystic fibrosis (CF). Additional knowledge of the performance of this biomarker is needed
to inform exploratory clinical trial design in support of programs to develop new inhaled
therapies for CF. We hypothesize that MCC/CC measurements can be used to determine the
durability of action of agents like hypertonic saline (HS) which increase epithelial lining
fluid height.