Aim:
Clinical RCT comparing functional results and recurrence rate following enzymatic treatment
vs. needle aponeurotomy.
Materials and methods:
30° or more contracture of only one metacarpophalangeal (MCP) joint contracture of one of the
three ulnar digits and less than 20° for the adjacent proximal interphalangeal (PIP) joint.
Patients with primary disease of the hand. Total of 80 patients needed to detect difference
of 13.5°.
1) Needle aponeurotomy 2) Clostridium Histolyticum treatment. Clinical follow ups 1,4 weeks,
16 weeks and 1,2 and 5 years. Functional outcome scores: URAM, Quick Dash, EQ5D, brief MHQ,
VAS pain and VAS patient satisfaction. Total passive extension contracture reduction,
recurrence rate and registration of complications.