Duloxetine Impact on Postoperative Pain Control and Outcomes

• Status: Not yet recruiting
• Trial end date: 2024-09-30
• Target enrollment: 0
• Participant gender: All

Summary

1. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative narcotic consumption.

2. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative pain, function, and quality of life.

3. Evaluate the correlation between preoperative screening tests (measuring pain centralization, anxiety, depression, and overall function) and patients' response to treatment (reduction in pain, anxiety, or depression and improvement in function).

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Scripps Health
• Treatments: Duloxetine Hydrochloride

Criteria

Inclusion Criteria:

• Age: > 24 years

• Male / Female not meeting any of the exclusion criteria

Exclusion Criteria:

• Age < 24 years

• Current use of antidepressant medications (including SSRI/SNRI, tricyclic, or Monoamine Oxidase Inhibitors)

• History of seizure disorder

• Diagnosis of bipolar disorder

• History of syncope/orthostatic hypotension

• Diagnosis of any condition with slowed gastric emptying

• History of suicidal ideation

• History of liver disease

• History of chronic kidney disease/renal impairment

• History of angle-closure glaucoma.