Dual Ovarian Stimulation (DUOSTIM) for Poor Ovarian Responders
Status:
Active, not recruiting
Trial end date:
2021-11-01
Target enrollment:
Participant gender:
Summary
During ovarian stimulation, all the follicles grow under the action of FSH, only the selected
follicles and with the faster growth are taken. However during this stimulation, other
smaller follicles are also recruited and sensitized, which may increase the selection of
follicles available on the follicular wave following. In patients with weak reserve this
potentiation has a great interest, and the sequence of 2 stimulations on the same cycle could
make it possible to obtain a larger number of oocytes and embryos, thus giving a better
chance of delivery than on 2 distinct cycles of stimulation. However, this is preliminary
data that needs to be confirmed with a randomized controlled trial. In this population of
poor prognosis, the use of FSH-associated LH activity may optimize the ovarian response to
stimulation, particularly the combination containing placental HCG (Fertistartkit®) that
obtaining a slightly higher number of oocytes than highly purified HMG (Menopur®).
Phase:
Phase 3
Details
Lead Sponsor:
Centre Hospitalier Intercommunal Creteil
Collaborators:
IBSA Institut Biochimique SA Laboratoires Genévrier