Dual MRI for Cardiopulmonary COVID-19 Long Haulers
Status:
Recruiting
Trial end date:
2022-12-30
Target enrollment:
Participant gender:
Summary
The next phase of the COVID-19 pandemic is likely to see a surge in an associated chronic
cardiopulmonary disease that will challenge health systems. Recovered patients are presenting
with persistent dyspnea at the Duke Pulmonary Post-COVID clinic. Evidence is now mounting
that recovered patients have significant residual pulmonary disease, while myocardial injury
has also been increasingly reported. To optimally care for these patients, Duke Pulmonary
study team must comprehensively assess and monitor the changes in cardiopulmonary function
and relate the changes to physiologic and quality of life outcomes. The study team will
deploy cutting-edge MRI to fully characterize cardiopulmonary function in enrolled 30
subjects (accrual 23 subjects) at time point 60-120 days post recovery and 6-9 months later.
Cardiac MRI will assess the myocardial status and right ventricular function, while
hyperpolarized 129Xe MRI will provide a 3D assessment of pulmonary ventilation, interstitial
barrier integrity, and pulmonary vascular hemodynamics. The overall objective outlined in
this study is to demonstrate the feasibility and value of comprehensive longitudinal imaging
characterization of cardiopulmonary structure and function in patients recovered from
Covid-19.