Dual FSH/HCG Trigger in Letrozole Stimulated Intrauterine Insemination Cycles in Women With Unexplained Infertility

• Status: Completed
• Trial end date: 2015-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

The objective of this study was to evaluate the outcome of follicle stimulating hormone (FSH) co-administration with human chorionic gonadotrophins trigger for women with unexplained infertility (UEI) and assigned for letrozole (LTZ) stimulated intrauterine insemination (IUI) cycles .

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Benha University
• Treatments: Chorionic Gonadotropin; Follicle Stimulating Hormone; Letrozole

Criteria

Inclusion Criteria:

• Unexplained infertility for more than 2 years

• Normal ovulation proved by midluteal serum progesterone level >5 ng/ml,

• Patent fallopian tubes confirmed by hysterosalpingography or laparoscopy

• Normal semen analysis according to the modified World Health Organization (WHO) criteria

• Normal hormonal profile (FSH, LH, prolactin and TSH) in the early follicular phase.

Exclusion Criteria:

• Other causes of infertility ( tubal factors, polycystic ovary syndrome (PCOS), endometriosis)

• Ovarian cysts,

• FSH >10 mIU/ml.

• Previous intrauterine insemination (IUI )cycles,

• Liver or kidney diseases,

• Hypersensitivity to the used medications.