Overview

Dry Eye Study With Cosopt® Over 8 Weeks in Patients With Open-Angle Glaucoma or Ocular Hypertension (0507A-152)(COMPLETED)

Status:
Completed
Trial end date:
2008-09-15
Target enrollment:
0
Participant gender:
All
Summary
To evaluate if preservative free cosopt is well tolerated in patients with Open angle glaucoma (OAG) or Ocular hypertension (OH) with dry eyes.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Merck Sharp & Dohme Corp.
Treatments:
Dorzolamide
Maleic acid
Timolol
Criteria
Inclusion Criteria:

- Adult patient with newly diagnosed and untreated for open-angle glaucoma or ocular
hypertension with an Intra-ocular Pressure (IOP) of > 27 mm Hg (in at least one eye)
and a baseline GSS SYMP-6 total score of 75 or less

- Patient is male or a female who is highly unlikely to conceive

- Patient has been recently diagnosed and is presently untreated for open-angle glaucoma
or ocular hypertension with an IOP of at least 27 mm Hg in at least one eye (patient's
worse eye)

- Patient already diagnosed with open-angle glaucoma or ocular hypertension and
untreated for at least 30 days are eligible for the study if they have an IOP of 27 mm
Hg or more in at least one eye

Exclusion Criteria:

- A history of any illness that, in the opinion of the investigator, might confound the
results of the study or pose additional risk by administering preservative free
dorzolamide-timolol (preservative-free Cosopt®)

- The presence of any fundus pathology likely to change during the study or to influence
IOP (background of diabetic retinopathy is permitted)

- Any contraindication to the use of preservative-free Cosopt® including:

- bronchospasm, including bronchial asthma or a history of bronchial asthma or chronic
obstructive pulmonary disease, sinus bradycardia, second or third degree AV block,
cardiac failure (grade III and IV), cardiogenic shock, severe renal impairment (serum
creatinine > 150 umol/L or creatinine clearance < 30 ml/min)

- Patient on:

- carbonic anhydrase inhibitor, concomitant systemic or dermatological medication known
to affect the IOP, e.g. clonidine, corticosteroids, oral beta-blocking agents. patient
on a non-glaucoma medication that contains a preservative agent, i.e. benzalkonium
chloride, benzododecinium bromide or stabilized oxychloro complex

- Patient with hypersensitivity to any component of preservative free
dorzolamide-timolol (preservative-free Cosopt®)