Drug Transporter Interaction Study PHENTRA_2015_KPUK
Status:
Completed
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
The objective of the present study is to contribute to establishing in vivo phenotyping
procedures for organic anionic transporter polypeptide 1B1 (OATP1B1), organic cation
transporters 1 and 2 (OCT1/2), multidrug and toxic compound extrusion transporters 1 and
2,kidney splice variant (MATE1/2K), organic anion transporters 1 and 3 (OAT1/3), and
p-glycoprotein (P-gp) transporters via a cocktail approach. To this end, marker substrates
for each of the respective transporters are administered as single doses in one period each
and as a cocktail in one period to 24 healthy volunteers, and phenotyping metrics are derived
from plasma and urine concentrations.
Phase:
Phase 4
Details
Lead Sponsor:
University of Cologne
Collaborators:
Institute for Biomedical and Pharmaceutical Research (IBMP), Nürnberg-Heroldsberg, Germany Umm Al-Qura University