Drug Interaction and Self Administration Studies of Compounds for Cocaine Use Disorder
Status:
Completed
Trial end date:
2018-07-19
Target enrollment:
Participant gender:
Summary
The overall goal of this project is to develop initial human data on effects of novel
compounds on safety (interactions with cocaine) and efficacy (subjective response to cocaine
and self administration data) in non-treatment seeking cocaine use disorder subjects. The
compound to be studied will be the 5-HT2CR agonist lorcaserin. Lorcaserin and other 5-HT2CR
agonists have been shown to reduce cocaine self-administration and cue reactivity in rodents.
In addition there is human safety data in non-cocaine using subjects for lorcaserin as it is
currently FDA approved for obesity, and safety data from a cocaine interaction study in
rodents , but there is no human cocaine interaction/PK data and no PD data to support
potential dosages for phase II clinical trials.