Overview

Drug Interaction Study of Darunavir/Ritonavir and Lopinavir/Ritonavir on GSK2248761 PK and CYP450 Probe Drugs

Status:
Completed
Trial end date:
2009-11-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to evaluate the effect of GSK2448761 on CYP450 metabolic probes and to evaluate the 2-way interaction between GSK2448761 and two ritonavir-boosted protease inhibitors that are commonly used in HIV-infected subjects.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
GlaxoSmithKline
Treatments:
Darunavir
Dextromethorphan
Flurbiprofen
Lopinavir
Midazolam
Ritonavir
Criteria
Inclusion Criteria:

- Healthy as determined by a responsible and experienced physician, based on a medical
evaluation including medical history, physical examination, laboratory tests and
cardiac monitoring.

- Male or female between 18 and 50 years of age inclusive, at the time of signing the
informed consent.

- A female subject is eligible to participate if she is of non-childbearing potential
(i.e., physiologically incapable of becoming pregnant).

- Male subjects must agree to use one of the contraception methods listed in the
protocol. This criterion must be followed from the time of the first dose of study
medication until the follow-up visit.

- Body weight >=50 kg for men and >=45 kg for women and body mass index (BMI) within the
range 18.5-31.0 kg/m2 (inclusive).

- Capable of giving written informed consent, which includes compliance with the
requirements and restrictions listed in the consent form.

Exclusion Criteria:

- As a result of the medical interview, physical examination, or screening
investigations, the Investigator considers the subject unfit for the study.

- The subject has a positive pre-study drug/alcohol screen.

- Unwilling to refrain from the use of illicit drugs and adhere to other protocol-stated
restrictions while participating in the study.

- History of regular alcohol consumption within 6 months of the study.

- Unwilling to abstain from alcohol for 48 hours prior to the start of dosing until
collection of the final pharmacokinetic sample during each treatment period.

- History or regular use of tobacco- or nicotine-containing products within 3 months
prior to screening.

- History/evidence of symptomatic arrhythmia, angina/ischemia, coronary artery bypass
grafting (CABG) surgery or percutaneous transluminal coronary angioplasty (PCTA) or
any clinically significant cardiac disease.

- History/evidence of clinically significant pulmonary disease.

- Current or chronic history of liver disease, or known hepatic or biliary abnormalities
(with the exception of Gilbert's syndrome or asymptomatic gallstones).

- Subjects with a pre-existing condition interfering with normal gastrointestinal
anatomy or motility, hepatic and/or renal function, that could interfere with the
absorption, metabolism, and/or excretion of the study drugs. Subjects with a history
of cholecystectomy should be excluded.

- The subject has participated in a clinical trial and has received an investigational
product within the following time period prior to the first dosing day in the current
study: 30 days, 5 half-lives or twice the duration of the biological effect of the
investigational product (whichever is longer).

- The subject has received GSK2248761 in a previous clinical trial.

- Use of prescription or non-prescription drugs, including vitamins, herbal and dietary
supplements (including St John's Wort) within 7 days (or 14 days if the drug is a
potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first
dose of study medication, unless in the opinion of the Investigator and GSK Medical
Monitor the medication will not interfere with the study procedures or compromise
subject safety.

- History of sensitivity to any of the study medications, or components thereof or a
history of drug or other allergy that, in the opinion of the investigator or GSK
Medical Monitor, contraindicates their participation.

- Where participation in the study would result in donation of blood or blood products
in excess of 500 mL within a 56 day period.

- Has a known intolerance or hypersensitivity to aspirin, NSAIDS, or benzodiazepines, or
a known intolerance to the active and/or inactive ingredients in dextromethorphan,
midazolam and flurbiprofen (Cohort 1 only)

- Has any condition or symptom contraindicated for administration of the study drugs:
dextromethorphan, midazolam and flurbiprofen. The Investigator should reference the
product information of each study drug. (Cohort 1 only)

- History of sensitivity to heparin or heparin-induced thrombocytopenia (if heparin is
used to maintain the patency of an intravenous cannula).

- A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
result within 3 months of screening.

- A positive test for HIV antibody.

- AST, ALT, alkaline phosphatase and bilirubin >=1.5xULN (isolated bilirubin >1.5xULN is
acceptable if bilirubin is fractionated and direct bilirubin <35%).

- Pregnant females as determined by positive serum hCG test at screening or prior to
dosing.

- Lactating females.

- The subject's systolic blood pressure is outside the range of 90-140mmHg, or diastolic
blood pressure is outside the range of 45-90mmHg or heart rate is outside the range of
50-100bpm for female subjects or 45-100 bpm for male subjects at Screening and Day -1.

- Cardiac conduction abnormalities denoted on a single 12-lead ECG at screening or Day
-1