Drug Interaction Study of Colchicine and Theophylline
Status:
Completed
Trial end date:
2012-07-01
Target enrollment:
Participant gender:
Summary
Colchicine is a supressor of hepatic CYP1A2 and theophylline is a sensitive CYP1A2 probe
substrate. When the two are co-administered the potential exists for a clinically significant
drug interaction. This study aims to determine the effect of steady-state colchicine on the
pharmacokinetics of theophylline administered as a single dose. A secondary goal is to
evaluate the safety and tolerability of this regimen in healthy volunteers. All study
subjects will be monitored for adverse events throughout the entire study period.