Overview

Drug Interaction Study To Investigate The Potential Effect Of Proton Pump Inhibitor On The Pharmacokinetics Of Palbociclib (PD-0332991)

Status:
Completed

Trial end date:
2013-12-01

Target enrollment:

Participant gender:

Summary

Fixed sequence, 2-period crossover study to compare the pharmacokinetic profiles of Palbociclib in absence and presence of prior administration of proton pump inhibitor Rabeprazole. The increased gastric pH achieved by the treatment with multiple doses of Rabeprazole might affect the absorption process of Palbociclib.

Phase:

Phase 1

Details

Lead Sponsor:

Pfizer

Treatments:

Palbociclib
Proton Pump Inhibitors
Rabeprazole