Drug Interaction Study Between Rifabutin And Lersivirine (UK-453,061)
Status:
Completed
Trial end date:
2010-08-01
Target enrollment:
Participant gender:
Summary
Approximately 1/3 of persons living with HIV infection are co-infected with tuberculosis
(TB). Rifabutin, used in the treatment of TB, is an inducer of drug metabolism thus may
decrease concentrations of lersivirine if co-administered. Lersivirine is a modest inducer of
drug metabolism, thus lersivirine may decrease concentrations of rifabutin as well.