Drug-Drug Interaction Study of Qualaquin and Midazolam
Status:
Completed
Trial end date:
2007-03-01
Target enrollment:
Participant gender:
Summary
This is an open label non-randomized single sequence, single group two way drug interaction
study in healthy adult volunteers to determine the extent to which quinine, an inducer of
cytochrome p450 CYP 3A4, affects the pharmacokinetics of midazolam, an accepted probe drug
for CYP 3A4. The study will also determine the extent to which midazolam affects the
pharmacokinetics of quinine.