Drug-Drug Interaction Study of Colchicine and Azithromycin
Status:
Completed
Trial end date:
2008-08-01
Target enrollment:
Participant gender:
Summary
Azithromycin is a possible weak to moderate inhibitor of CYP3A4, one of the enzymes
responsible for the metabolism of colchicine. This study will evaluate the effect of multiple
doses of azithromycin on the pharmacokinetic profile of a single 0.6 mg dose of colchicine. A
secondary objective is to evaluate the safety and tolerability of this regimen in healthy
volunteers. All study subjects will be monitored for adverse events throughout the study
period.