Drug-Drug Interaction Study of AG120 in Healthy Subjects
Status:
Completed
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
An Open-Label, 2-Period, Fixed Sequence Study to Determine the Effect of Multiple Oral Doses
of Itraconazole on the Single Dose Pharmacokinetics of AG 120 in Healthy Adult Subjects.
Period 1 consists of a single oral dose of AG-120 will be administered at Hour 0 followed by
PK sampling for 504 hours (21 days). In Period 2, multiple oral doses of itraconazole will be
administered once daily (QD) for 18 consecutive days with a single oral dose of AG-120
coadministered at Hour 0 on Day 1. PK sampling for AG-120 will be taken for 504 hours (21
days) following AG-120 dosing on Day 1.