Drug-Drug Interaction Study With Pravastatin and Cyclosporine
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
This study will address the following question: Does cyclosporine affect the pharmacokinetics
of pravastatin in healthy volunteers? Studies have shown that cyclosporine inhibits the
organic anion transporter required for pravastatin transport into the liver, thus increasing
pravastatin levels in the blood. The investigators hypothesize that this inhibition will vary
among people based on genetic differences. This knowledge is important to help develop safer
and more effective drug therapy with reduced side effects.
Phase:
Phase 1
Details
Lead Sponsor:
University of California, San Francisco
Collaborator:
National Institute of General Medical Sciences (NIGMS)