Drug-Drug Interaction Study With Metformin and Nizatidine
Status:
Completed
Trial end date:
2013-03-01
Target enrollment:
Participant gender:
Summary
This study will address the following question: Does nizatidine affect the pharmacokinetics
of metformin in healthy volunteers? Recent studies in the Giacomini laboratory have indicated
that nizatidine may block metformin elimination from the kidney by inhibiting organic cation
transporter efflux of metformin. The investigators hypothesize that the co-administration of
metformin and nizatidine will reduce the renal clearance (CLR) of metformin leading to
increased plasma concentrations and potential risk for toxicities. Knowledge of the
pharmacokinetic interaction profile of metformin with organic transporter inhibitors, such as
nizatidine, is important to help develop safer more effective drug therapy with reduced side
effects.
Phase:
Phase 1
Details
Lead Sponsor:
University of California, San Francisco
Collaborator:
National Institute of General Medical Sciences (NIGMS)